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PPM1A antibody [p6c7]

Anti-PPM1A antibody [p6c7] used in Western Blot (WB). GTX53766
Anti-PPM1A antibody [p6c7] used in Western Blot (WB). GTX53766
Anti-PPM1A antibody [p6c7] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX53766

Cat No. GTX53766

Host

Mouse

Clonality

Monoclonal

Clone Name

p6c7

Isotype

IgG2b

Application

WB, ICC/IF, ELISA

Reactivity

Human, Mouse
Package
100 μl ($319)

APPLICATION

Application Note

ELISA: Assay-dependent dilution
WB: 1:250- 1:1000
ICC/IF: 1:100
Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

42 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS(pH 7.4) with 10% Glycerol, 0.02% Sodium Azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human PP2C alpha (1-382aa) purified from E. coli

Purification

By protein-G affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Protein Phosphatase, Mg2+/Mn2+ Dependent 1A , Pp2C-Alpha , Pp2Ca , Pp2Calpha , Ppm1A

Background

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-PPM1A antibody [p6c7] used in Western Blot (WB). GTX53766

GTX53766 WB Image

PPM1A antibody detects PPM1A protein by western blot analysis.
1. 40 μg Mouse kidney tissue lysate
2. 40 μg Mouse brain tissue lysate
3. 40 μg Mouse liver tissue lysate
PPM1A antibody (GTX53766) dilution: 1:1000

Anti-PPM1A antibody [p6c7] used in Western Blot (WB). GTX53766

GTX53766 WB Image

PPM1A antibody detects PPM1A protein by western blot analysis.
1. 40 μg Jurkat cell lysate
2. 40 μg HeLa cell lysate
3. 40 μg K562 cell lysate
4. 40 μg MCF7 cell lysate
5. 40 μg A549 cell lysate
6. 40 μg Raji cell lysate
PPM1A antibody (GTX53766) dilution: 1:1000

Anti-PPM1A antibody [p6c7] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX53766

GTX53766 ICC/IF Image

PPM1A antibody detects PPM1A protein in HeLa cells by immunofluorescent analysis.
PPM1A antibody (GTX53766) dilution: 1:100

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 319