GeneTex
United States (US)

PR3 antibody [1F11]

Cat No. GTX10199

Host Mouse
Clonality Monoclonal
Clone Name 1F11
Isotype IgG2a
Application ELISA
Reactivity Human
APPLICATION

Application Note

ELISA: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

28 kDa. ( Note )

Specificity/Sensitivity

GTX10197, 10198, 10199, 10200 and 10201 detect different determinants of proteinase PR3 which have not been fully determined.
PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.4, containing 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1.6mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human proteinase PR3 purified leukocyte mass

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP4, P29, PR-3, PR3, PR 3, C ANCA

Background

Proteinase 3 plays a role in neutrophil response to inflammation. Myeloblastin (PR3) is a polymorphonuclear leukocyte serine protease which degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.

Database

Package List Price ($)
$ 219