GeneTex
United States (US)

PSA antibody [ER-PR8]

Cat No. GTX28681

Host Mouse
Clonality Monoclonal
Clone Name ER-PR8
Isotype IgG1
Application WB, IHC-P
Reactivity Human
APPLICATION

Application Note

For IHC-P: Use at a dilution of 1:100. For WB: Use at a dilution of 1:200. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

29 kDa. ( Note )

Positive Control

LNCaP cells. Normal prostate or prostate carcinoma.

Specificity/Sensitivity

Reacts with the 33 kD human prostate specific antigen.
PROPERTIES

Form

Liquid

Buffer

10mM Phosphate-buffered saline, pH 7.4 containing 0.2% BSA and 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified human prostate specific antigen.

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Kallikrein Related Peptidase 3,Aps,Klk2A1,Psa,Hk3,Klk3

Cellular Localization

Cytoplasmic

Background

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates two transcript variants encoding different isoforms. Additional transcript variants have been described, but it is unclear if these transcripts are normally expressed or if they are specific to benign or malignant tumors.

Database

Package List Price ($)
$ 319