This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
IHC-P analysis of human medulla oblongata using GTX80151 PSMA antibody [GCP-04].
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GTX80151 IHC-P Image
IHC-P analysis of pig kidney tissue using GTX80151 PSMA antibody [GCP-04].
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GTX80151 IHC-P Image
IHC-P analysis of human prostate tissue using GTX80151 PSMA antibody [GCP-04].
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GTX80151 WB Image
WB analysis of human GCPII (aminoacids 44-750) overexpressed in S2 cells using GTX80151 PSMA antibody [GCP-04]. Lanes 1, 2, 3 represent 800, 400 and 200 pg of the protein.