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PSMA antibody [GCP-04]

Anti-PSMA antibody [GCP-04] used in IHC (Paraffin sections) (IHC-P). GTX80151
Anti-PSMA antibody [GCP-04] used in IHC (Paraffin sections) (IHC-P). GTX80151
Anti-PSMA antibody [GCP-04] used in IHC (Paraffin sections) (IHC-P). GTX80151
Anti-PSMA antibody [GCP-04] used in Western Blot (WB). GTX80151

Cat. No. GTX80151

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 GCP-04

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human, Mouse, Rat, Pig
Package
100 μg ($399)
See all PSMA products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

84 kDa. ( Note )

Product Note

This antibody recognizes amino acids 100-104 of extracellular domain of denaturated glutamate carboxypeptidase II (PSMA, NAALADase, FOLH1).

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment of human GCPII (amino acids 44-750) produced in S2 cells

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

FGCP , FOLH , FOLH1 , GCP2 , GCPII , NAALAD1 , NAALAdase , PSM , PSMA , folate hydrolase 1 , mGCP

Cellular Localization

Cell membrane,Cytoplasm

Background

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]

Database

Research Area

DATA IMAGES

Anti-PSMA antibody [GCP-04] used in IHC (Paraffin sections) (IHC-P). GTX80151

GTX80151 IHC-P Image

IHC-P analysis of human prostate tissue using GTX80151 PSMA antibody [GCP-04].

Anti-PSMA antibody [GCP-04] used in IHC (Paraffin sections) (IHC-P). GTX80151

GTX80151 IHC-P Image

IHC-P analysis of pig kidney tissue using GTX80151 PSMA antibody [GCP-04].

Anti-PSMA antibody [GCP-04] used in IHC (Paraffin sections) (IHC-P). GTX80151

GTX80151 IHC-P Image

IHC-P analysis of human medulla oblongata using GTX80151 PSMA antibody [GCP-04].

Anti-PSMA antibody [GCP-04] used in Western Blot (WB). GTX80151

GTX80151 WB Image

WB analysis of human GCPII (aminoacids 44-750) overexpressed in S2 cells using GTX80151 PSMA antibody [GCP-04]. Lanes 1, 2, 3 represent 800, 400 and 200 pg of the protein.

REFERENCE

Application Reference

Ji T et al. CNS Neurosci Ther 2023; 29 (12) : 3786-3801 Deletion of glutamate carboxypeptidase II (GCPII), but not GCPIII, provided long-term benefits in mice with traumatic brain injury.
Vallejo-Armenta P et al. Nucl Med Biol 2021; 96-97 : 1-8 [99mTc]Tc-iPSMA SPECT brain imaging as a potential specific diagnosis of metastatic brain tumors and high-grade gliomas.
Application : IHC-P
Reactivity : Human
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399