*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
This antibody recognizes extracellular domain (preferentially in native form) of glutamate carboxypeptidase II (NAALADase, FOLH1, PSMA).
15mM Sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.
0.1 mg/ml (Please refer to the vial label for the specific concentration.)
amino acids 44-750 of human GCPII
Purified by size-exclusion chromatography
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
FGCP , FOLH , FOLH1 , GCP2 , GCPII , NAALAD1 , NAALAdase , PSM , PSMA , folate hydrolase 1 , mGCP
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
GTX80150 FACS Image
Flow cytometry analysis of GCPII (PSMA) by various monoclonal antibodies: GCP-01, GCP-02, GCP-04, GCP-05 (GTX80149) on LNCaP cell line.
green column - 1 μg/ml, LNCaP cell line
blue column - 5 μg/ml, LNCaP cell line
yellow column - negative cell line
GTX80150 FACS Image
Flow cytometry analysis of GCPII (PSMA) using anti-GCPII (GCP-05) (GTX80149) and goat anti-mouse-PE on LNCaP cell line (positive, green) and HeLa cells (negative, blue).