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PSMA antibody [GCP-05] (PE)

Anti-PSMA antibody [GCP-05] (PE) used in Flow cytometry (FACS). GTX80150
Anti-PSMA antibody [GCP-05] (PE) used in Flow cytometry (FACS). GTX80150

Cat No. GTX80150

Host

Mouse

Clonality

Monoclonal

Clone Name

GCP-05

Isotype

IgG1

Application

FACS

Reactivity

Human
Package
100 μg ($359)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
FACS Assay dependent
Not tested in other applications.

Calculated MW

84 kDa. ( Note )

Product Note

This antibody recognizes extracellular domain (preferentially in native form) of glutamate carboxypeptidase II (NAALADase, FOLH1, PSMA).

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

0.1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

amino acids 44-750 of human GCPII

Purification

Purified by size-exclusion chromatography

Conjugation

Phycoerythrin (PE)

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

FGCP , FOLH , FOLH1 , GCP2 , GCPII , NAALAD1 , NAALAdase , PSM , PSMA , folate hydrolase 1 , mGCP

Cellular Localization

Cell membrane,Cytoplasm

Background

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]

Database

Research Area

DATA IMAGES

Anti-PSMA antibody [GCP-05] (PE) used in Flow cytometry (FACS). GTX80150

GTX80150 FACS Image

Flow cytometry analysis of GCPII (PSMA) by various monoclonal antibodies: GCP-01, GCP-02, GCP-04, GCP-05 (GTX80149) on LNCaP cell line.
Legend:
green column - 1 μg/ml, LNCaP cell line
blue column - 5 μg/ml, LNCaP cell line
yellow column - negative cell line

Anti-PSMA antibody [GCP-05] (PE) used in Flow cytometry (FACS). GTX80150

GTX80150 FACS Image

Flow cytometry analysis of GCPII (PSMA) using anti-GCPII (GCP-05) (GTX80149) and goat anti-mouse-PE on LNCaP cell line (positive, green) and HeLa cells (negative, blue).

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 359