APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| Assay dependent |
| Assay dependent |
| Assay dependent |
| Assay dependent |
Not tested in other applications.
Calculated MW
Product Note
This antibody recognizes extracellular domain (preferentially in native form) of glutamate carboxypeptidase II (NAALADase, FOLH1, PSMA).
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
15mM Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
amino acids 44-750 of human GCPII
Purification
Protein A purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
FGCP , FOLH , FOLH1 , GCP2 , GCPII , NAALAD1 , NAALAdase , PSM , PSMA , folate hydrolase 1 , mGCP
Cellular Localization
Cell membrane,Cytoplasm
Background
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
Database
Research Area
DATA IMAGES
![Anti-PSMA antibody [GCP-05] used in Flow cytometry (FACS). GTX80149](/templates/default/js/lightbox/images/loading.gif "Anti-PSMA antibody [GCP-05] used in Flow cytometry (FACS). GTX80149")
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GTX80149 FACS Image
FACS analysis of LNCaP (positive, green) and HeLa (negative, blue) cells using GTX80149 PSMA antibody [GCP-05].
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REFERENCE
There are currently no references for PSMA antibody [GCP-05] (GTX80149). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for PSMA antibody [GCP-05] (GTX80149). Be the first to share your experience with this product.
![Anti-PSMA antibody [GCP-05] used in Flow cytometry (FACS). GTX80149](/upload/website/prouct_img/small/GTX80149/GTX80149_20191025_AP_006_391_w_23061322_987.webp "Anti-PSMA antibody [GCP-05] used in Flow cytometry (FACS). GTX80149")
![Anti-PSMA antibody [GCP-05] used in Flow cytometry (FACS). GTX80149](/upload/website/prouct_img/normal/GTX80149/GTX80149_20191025_AP_006_391_w_23061322_987.webp "Anti-PSMA antibody [GCP-05] used in Flow cytometry (FACS). GTX80149")