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PSMA antibody [YPSMA-1]

Cat No. GTX19071

Host

Mouse

Clonality

Monoclonal

Clone Name

YPSMA-1

Isotype

IgG2b

Application

WB, ICC/IF, IHC-P, IHC-Fr, ELISA

Reactivity

Human
Package
250 μg ($319)

APPLICATION

Application Note

For ELISA: Use at an assay dependent dilution. For IF: Use at an assay dependent dilution. For IHC-Fr: Use at an assay dependent dilution. For IHC-P: Use at an assay dependent dilution. For WB: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

84 kDa. ( Note )

Positive Control

LNCaP cell line

Product Note

Minimal or no cross-reactivity to benign prostate hyperplasia (BPH) or to normal prostatic tissue.

PROPERTIES

Form

Liquid

Buffer

0.01M PBS pH7.0

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Crude membrane protein preparation from pooled prostate malignant carcinoma from China.

Purification

Protein G purified

Conjugation

Unconjugated

RRID

AB_423409

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

folate hydrolase 1 , FGCP , FOLH , GCP2 , GCPII , NAALAD1 , NAALAdase , PSM , PSMA , mGCP

Cellular Localization

Cell membrane

Background

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]

Database

Research Area

REFERENCE

REVIEW

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Package List Price ($)
$ 319
Custom Conjugations