PSMA7 antibody [8F9]

Cat. No. GTX83785

Host	Mouse
Clonality	Monoclonal
Clone Name	8F9
Isotype	IgG2a
Application	WB, ICC/IF, FACS
Reactivity	Human
Package	100 μl ($519)

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Datasheet
Document

View product citations for antibody GTX83785 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1:2000
ICC/IF	1:100
FACS	1:100

Not tested in other applications.

Calculated MW

28 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.68 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Full length human recombinant protein of human PSMA7 (NP_002783) produced in HEK293T cell.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

proteasome subunit alpha 7 , C6 , HEL-S-276 , HSPC , RC6-1 , XAPC7

Cellular Localization

Cytoplasm,Nucleus

Background

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.

Database

Gene ID: 5688 PSMA7
UniProt: O14818 PSMA7

Research Area

DATA IMAGES

GTX83785 WB Image

WB analysis of HEK293T cells transfected with PSMA7 plasmid (Right) or empty vector (Left) for 48 hrs using GTX83785 PSMA7 antibody [8F9].
Loading : 5 ug per lane

GTX83785 ICC/IF Image

ICC/IF analysis of COS7 cells transiently transfected with PSMA7 plasmid using GTX83785 PSMA7 antibody [8F9].

GTX83785 FACS Image

FACS analysis of Jurkat cells using GTX83785 PSMA7 antibody [8F9].
Red : Primary antibody
Blue : Negative control antibody

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf

Package

List Price ($)

100 μl

$ 519

Qty