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PTBP1 antibody

Anti-PTBP1 antibody used in Western Blot (WB). GTX54619
Anti-PTBP1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX54619
Anti-PTBP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX54619
Anti-PTBP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX54619
Anti-PTBP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX54619

Cat. No. GTX54619

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all PTBP1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
ICC/IF 1:50 - 1:100
IHC-P 1:50 - 1:100
Not tested in other applications.

Calculated MW

57 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human PTBP1 (NP_114368.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

polypyrimidine tract binding protein 1 , HNRNP-I , HNRNPI , HNRPI , PTB , PTB-1 , PTB-T , PTB2 , PTB3 , PTB4 , pPTB

Cellular Localization

Nucleus

Background

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-PTBP1 antibody used in Western Blot (WB). GTX54619

GTX54619 WB Image

WB analysis of various sample lysates using GTX54619 PTBP1 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-PTBP1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX54619

GTX54619 ICC/IF Image

ICC/IF analysis of U2OS cells using GTX54619 PTBP1 antibody.
Blue : DAPI
Dilution : 1:50

Anti-PTBP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX54619

GTX54619 IHC-P Image

IHC-P analysis of human colon tissue using GTX54619 PTBP1 antibody.
Dilution : 1:100

Anti-PTBP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX54619

GTX54619 IHC-P Image

IHC-P analysis of rat spleen tissue using GTX54619 PTBP1 antibody.
Dilution : 1:100

Anti-PTBP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX54619

GTX54619 IHC-P Image

IHC-P analysis of mouse kidney tissue using GTX54619 PTBP1 antibody.
Dilution : 1:100

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399