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PTEN antibody [2C10]

Anti-PTEN antibody [2C10] used in IHC (Paraffin sections) (IHC-P). GTX34150

Cat No. GTX34150

Host Mouse
Clonality Monoclonal
Clone Name 2C10
Isotype IgG1
Application IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

47 kDa. ( Note )

Specificity/Sensitivity

PTEN Mouse Monoclonal Antibody (2C10) detects endogenous levels of PTEN
PROPERTIES

Form

Liquid

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Synthetic Peptide of PTEN

Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Phosphatase And Tensin Homolog,10Q23Del,Bzs,Cws1,Dec,Glm2,Mham,Mmac1,Pten1,Ptenbeta,Tep1,Pten

Background

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
Anti-PTEN antibody [2C10] used in IHC (Paraffin sections) (IHC-P). GTX34150

GTX34150 IHC-P Image

Immunohistochemistry (IHC) analysis of paraffin-embedded Human Colon Carcinoma Tissue using PTEN Mouse Monoclonal Antibody diluted at 1:200.

Package List Price ($)
$ 319