APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| Assay dependent |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
The peptide used to generate this antibody is available for purchase (GTX88020-PEP).
Product Note
This antibody is expected to recognize both reported isoforms (NP_001103224.1; NP_002828.3).
Predict Reactivity
Rat, Bovine, Dog, Pig(>80% identity)
PROPERTIES
Form
Liquid
Buffer
TBS, 0.5% BSA
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.50 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Peptide with sequence C-ENHSFSQERTVPDK, from the internal region of the protein sequence according to NP_001103224.1; NP_002828.3.
Purification
Purified by ammonium sulphate precipitation followed by antigen affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
protein tyrosine phosphatase receptor type B , HPTP-BETA , HPTPB , PTPB , R-PTP-BETA , VEPTP
Cellular Localization
Membrane
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Database
Research Area
DATA IMAGES
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GTX88020 ICC/IF Image
ICC/IF analysis of PFA-fixed A431 cells using GTX88020 PTPRB antibody, Internal.
Negative control (-ve) : Unimmunized goat IgG
Permeabilization : 0.15% Triton
Dilution : 10ug/ml
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GTX88020 FACS Image
FACS analysis of PFA-fixed A431 cells using GTX88020 PTPRB antibody, Internal.
Blue : Primary antibody
Black : Unimmunized goat IgG
Permeabilization : 0.5% Triton
Dilution : 10ug/ml
|
REFERENCE
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REVIEW
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