PTPRE antibody [4B2]

Cat. No. GTX83763

Host	Mouse
Clonality	Monoclonal
Clone Name	4B2
Isotype	IgG2a
Application	WB, ICC/IF, IHC-P, FACS
Reactivity	Human, Monkey
Package	100 μl ($519)

See all PTPRE products

Datasheet
Document

View product citations for antibody GTX83763 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1:2000
ICC/IF	1:100
IHC-P	1:50
FACS	1:50

Not tested in other applications.

Calculated MW

81 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.89 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Full length human recombinant protein of human PTPRE (NP_006495) produced in HEK293T cell.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

protein tyrosine phosphatase receptor type E , HPTPE , PTPE , R-PTP-EPSILON

Background

Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function. Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake. Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).

Database

Gene ID: 5791 PTPRE
UniProt: P23469 PTPRE

Research Area

DATA IMAGES

GTX83763 IHC-P Image

IHC-P analysis of human prostate carcinoma tissue using GTX83763 PTPRE antibody [4B2].
Antigen retrieval : Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120ººC for 3 min.

GTX83763 FACS Image

FACS analysis of Malme-3M cells using GTX83763 PTPRE antibody [4B2].
Red : Primary antibody
Blue : no antibody control

GTX83763 WB Image

WB analysis of HEK293T cells transfected with PTPRE plasmid (Right) or empty vector (Left) for 48 hrs using GTX83763 PTPRE antibody [4B2].
Loading : 5 ug per lane

GTX83763 IHC-P Image

IHC-P analysis of human kidney tissue using GTX83763 PTPRE antibody [4B2].
Antigen retrieval : Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120ººC for 3 min.

GTX83763 IHC-P Image

IHC-P analysis of human pancreas tissue using GTX83763 PTPRE antibody [4B2].
Antigen retrieval : Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120ººC for 3 min.

GTX83763 IHC-P Image

IHC-P analysis of human liver carcinoma tissue using GTX83763 PTPRE antibody [4B2].
Antigen retrieval : Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120ººC for 3 min.

GTX83763 WB Image

WB analysis of HepG2 and COS-7 cell lysate using GTX83763 PTPRE antibody [4B2].
Loading : 10 ug per lane
Dilution : 1:200

GTX83763 IHC-P Image

IHC-P analysis of human ovary adenocarcinoma tissue using GTX83763 PTPRE antibody [4B2].
Antigen retrieval : Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120ººC for 3 min.

GTX83763 ICC/IF Image

ICC/IF analysis of COS7 cells transiently transfected with PTPRE plasmid using GTX83763 PTPRE antibody [4B2].

GTX83763 IHC-P Image

IHC-P analysis of human liver tissue using GTX83763 PTPRE antibody [4B2].
Antigen retrieval : Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120ººC for 3 min.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf

Package

List Price ($)

100 μl

$ 519

Qty

PTPRE antibody [4B2]

Cat. No. GTX83763

Host

Clonality

Clone Name

Isotype

Application

Reactivity

APPLICATION

Application Note

Calculated MW

PROPERTIES

Form

Buffer

Preservative

Storage

Concentration

Antigen Species

Immunogen

Purification

Conjugation

Note

TARGET

Synonyms

Background

Database

Research Area

DATA IMAGES

GTX83763 IHC-P Image

GTX83763 FACS Image

GTX83763 WB Image

GTX83763 IHC-P Image

GTX83763 IHC-P Image

GTX83763 IHC-P Image

GTX83763 WB Image

GTX83763 IHC-P Image

GTX83763 ICC/IF Image

GTX83763 IHC-P Image

REFERENCE

REVIEW

Product

Research

Support

Company

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