GeneTex
United States (US)

PTPRN antibody, Internal

GTX88611_2125_WB_18122102_188.jpg

Cat No. GTX88611

Host Goat
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Mouse
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5-1.5μg/ml
Not tested in other applications.

Calculated MW

106 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX88611-PEP).

Predict Reactivity

Human, Rat(>80% identity)
PROPERTIES

Form

Liquid

Buffer

Tris saline pH7.3, 0.02% sodium azide, 0.5% BSA.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.50 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide with sequence C-QGEGNIKKNRHPD, from the internal region of the protein sequence according to NP_002837.1.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Protein Tyrosine Phosphatase, Receptor Type N,Ia-2,Ia-2/Ptp,Ia2,Ica512,R-Ptp-N,Ptprn

Cellular Localization

Neuroendocrine secretory granules.

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

Database

Research Area

DATA IMAGES
GTX88611_2125_WB_18122102_188.jpg

GTX88611 WB Image

WB analysis of NIH-3T3 lysate using GTX88611 PTPRN antibody, Internal.
Dilution : 0.5µg/ml
Loading : 35µg protein in RIPA buffer

Package List Price ($)
$ 329