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PUMA antibody

Anti-PUMA antibody used in Western Blot (WB). GTX70455
Anti-PUMA antibody used in Western Blot (WB). GTX70455

Cat. No. GTX70455

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB

Reactivity

 Human
Package
100 μg ($399)
See all PUMA products

APPLICATION

Application Note

For WB: Use at a dilution of 1:500-1:1,000. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

26 kDa. ( Note )

Product Note

A 17 residue sequence [EQHLESPVPSAPGALAG] found in the exon-3-encoded region in the human PUMA-a and PUMA-b forms of the protein. Recognizes both forms of the protein.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Purification

Affinity purified IgG

Conjugation

Unconjugated

RRID

AB_374146

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Bcl2 Binding Component 3 , Jfy-1 , Jfy1 , Puma , Bbc3

Background

A novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.

Research Area

DATA IMAGES

Anti-PUMA antibody used in Western Blot (WB). GTX70455

GTX70455 WB Image

Anti-PUMA antibody used in Western Blot (WB). GTX70455

GTX70455 WB Image

Western blot analysis of PUMA from transfected U20S cell lysate.

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399