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PUMA antibody

Anti-PUMA antibody used in Western Blot (WB). GTX70455
Anti-PUMA antibody used in Western Blot (WB). GTX70455

Cat No. GTX70455

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB

Reactivity

Human
Package
100 μg ($289)

APPLICATION

Application Note

For WB: Use at a dilution of 1:500-1:1,000. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

26 kDa. ( Note )

Specificity/Sensitivity

A 17 residue sequence [EQHLESPVPSAPGALAG] found in the exon-3-encoded region in the human PUMA-a and PUMA-b forms of the protein. Recognizes both forms of the protein.

PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline containing 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Purification

Affinity purified IgG

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Bcl2 Binding Component 3 , Jfy-1 , Jfy1 , Puma , Bbc3

Background

A novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.

Research Area

DATA IMAGES

Anti-PUMA antibody used in Western Blot (WB). GTX70455

GTX70455 WB Image

Western blot analysis of PUMA from transfected U20S cell lysate.

Anti-PUMA antibody used in Western Blot (WB). GTX70455

GTX70455 WB Image

REFERENCE

There are currently no references for PUMA antibody (GTX70455). Be the first to share your publications with this product.

REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 289