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PYK2 antibody

Anti-PYK2 antibody used in Western Blot (WB). GTX16672

Cat. No. GTX16672

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IP

Reactivity

 Human, Mouse
Package
125 μg ($419)
See all PYK2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.5-2μg/ml
IP 4μg antibody/ 500μg lysate
Not tested in other applications.

Calculated MW

116 kDa. ( Note )

Product Note

Does not crossreact with FAK.

PROPERTIES

Form

Liquid

Buffer

0.1M Tris-Glycine pH7.4, 0.15M Sodium Chloride

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

GST fusion protein containing aa726-863 of human Pyk2

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CADTK , CAKB , FADK2 , FAK2 , PKB , PTK , PTK2B , PYK2 , RAFTK , protein tyrosine kinase 2 beta

Cellular Localization

Cytoplasm,Perinuclear region,Cell membrane,Cell junction,Focal adhesion,Cell projection,Lamellipodium,Cell cortex,Nucleus

Background

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-PYK2 antibody used in Western Blot (WB). GTX16672

GTX16672 WB Image

WB analysis of mouse brain tissue lysate using GTX16672 PYK2 antibody.
Dilution : 0.5μg/ml

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 419