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Pan NaV antibody

Anti-Pan NaV antibody used in Western Blot (WB). GTX16935
Anti-Pan NaV antibody used in IHC (Frozen sections) (IHC-Fr). GTX16935

Cat. No. GTX16935

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-Fr, IP

Reactivity

 Human, Mouse, Rat
Package
50 μl ($639)
See all Pan NaV products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-Fr Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

229 kDa. ( Note )

Product Note

This antibody is directed against an intracellular epitope of the rat NaV1.1 channel that is identical in all isoforms of NaV1 in all vertebrates, and highly homologous in molluscan and insect voltage-gated Na+ channels.

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

Peptide TEEQKKYYNAMKKLGSKK(C), corresponding to amino acid residues 1501-1518 (Intracellular loop between domains III and IV) of rat NaV1.1 (Accession  : P04774).

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

sodium voltage-gated channel alpha subunit 1

Cellular Localization

Cell membrane

Background

has voltage gated sodium ion channel activity; plays a role in generation of action potential [RGD, Feb 2006]

Database

Research Area

DATA IMAGES

Anti-Pan NaV antibody used in Western Blot (WB). GTX16935

GTX16935 WB Image

WB analysis of rat brain membrane lysate using GTX16935 Pan NaV Antibody preincubated with or without immunogen peptide.
Dilution : 1:200

Anti-Pan NaV antibody used in IHC (Frozen sections) (IHC-Fr). GTX16935

GTX16935 IHC-Fr Image

IHC-Fr analysis of rat cerebellum tissue using GTX16935 Pan NaV Antibody.
Panel A : NaV channels (red) appear in Purkinje cell bodies (vertical arrows) and in cells of the molecular layer (Mol), (horizontal arrows).
Panel B : Staining of Parvalbumin (green) in the same brain section.
Panel C : Merge of NaV channels and Parvalbumin demonstrates the location of NaV channels to the cell body of Purkinje neurons.

REFERENCE

Application Reference

Kuijpers M et al. Neuron 2021; 109 (2) : 299-313.e9 Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 639