GeneTex
United States (US)

Pan NaV Antibody

GTX16935_WB_18121410_825.jpg
GTX16935_IHC_18121410_843.jpg

Cat No. GTX16935

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF, IP, IHC
Reactivity Human, Mouse, Rat
APPLICATION

Specificity/Sensitivity

This antibody directed against an intracellular epitope of the rat NaV1.1 channel that is identical in all isoforms of NaV1 in all vertebrates, and highly homologous in molluscan and insect voltage-gated Na+ channels.
PROPERTIES

Form

Liquid

Buffer

Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Rat

Immunogen

Peptide TEEQKKYYNAMKKLGSKK(C), corresponding to amino acid residues 1501-1518 of rat Nav1.1 (Accession P04774). Intracellular loop between domains III and IV.

Purification

Affinity purified on immobilized antigen.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Background

has voltage gated sodium ion channel activity; plays a role in generation of action potential [RGD, Feb 2006]
DATA IMAGES
GTX16935_WB_18121410_825.jpg

GTX16935 WB Image

Anti-Pan_NaV - Western blot analysis of rat brain membranes: 1. Anti-Pan Nav antibody, (1:200). 2. Anti-Pan Nav antibody, preincubated with the control peptide antigen.

GTX16935_IHC_18121410_843.jpg

GTX16935 IHC Image

Anti-Pan_NaV - Expression of Nav channels in rat cerebellum Immunohistochemical staining of rat cerebellum using Anti-Pan Nav antibody. A. Nav channels (red) appear in Purkinje cell bodies (vertical arrows) and in cells of the molecular layer (Mol), (horizontal arrows). B. Staining of Parvalbumin (green) in the same brain section. C. Confocal merge of Nav channels and Parvalbumin demonstrates the location of Nav channels to the cell body of Purkinje neurons.

Package List Price ($)
$ 329