GeneTex
United States (US)

Parathyroid Hormone antibody [PTH/1175]

GTX34953_20170712_IHC-P_18121410_837.jpg
GTX34953_20170712_IHC-P_1_18121410_188.jpg

Cat No. GTX34953

Host Mouse
Clonality Monoclonal
Clone Name PTH/1175
Isotype IgG2b
Application IHC-P
Reactivity Human
APPLICATION

Application Note

IHC-P:0.5-1.0ug/ml for 30 minutes at RT.

Calculated MW

13 kDa. ( Note )

Specificity/Sensitivity

Epitope of this MAb maps in the C-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant human PTH protein fragment (aa32-115) (exact sequence is proprietary)

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Parathyroid Hormone,Pth1,Pth

Background

The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
GTX34953_20170712_IHC-P_18121410_837.jpg

GTX34953 IHC-P Image

Formalin-fixed, paraffin-embedded human Parathyroid stained with PTH Monoclonal Antibody (PTH/1175).

GTX34953_20170712_IHC-P_1_18121410_188.jpg

GTX34953 IHC-P Image

Formalin-fixed, paraffin-embedded human Parathyroid stained with PTH Monoclonal Antibody (PTH/1175).

Package List Price ($)
$ 329