APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| Assay dependent |
| Assay dependent |
Not tested in other applications.
Calculated MW
Product Note
Peptide tyrosine-tyrosine amide (3-36), or PYY(3-36), is a major metabolite of the gut hormone PYY and is produced by the action of dipeptidyl peptidase IV on PYY in the intestinal brush border and in the circulation. PYY(3-36) is a potent inhibitor of food intake in rats and humans, acting selectively on the Y2 receptor to inhibit orexigenic NPY neurons in the arcuate nucleus, thus disinhibiting anorexigenic POMC neurons. The anorexigenic effect of PYY(3-36) is additive to that of the co-secreted gut hormone GLP-1.
PROPERTIES
Form
Liquid
Buffer
0.01M Phosphate buffer, 0.5M NaCl
Preservative
15mM Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic N-terminal fragment of human PYY(3-36) coupled to carrier
Purification
Protein-A purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
peptide YY , PYY-I , PYY1
Cellular Localization
Secreted
Background
This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]
Database
Research Area
DATA IMAGES
![Anti-Peptide YY antibody [04] used in ELISA (ELISA). GTX60990](/templates/default/js/lightbox/images/loading.gif "Anti-Peptide YY antibody [04] used in ELISA (ELISA). GTX60990")
|
GTX60990 ELISA Image
The calibration curve of a sandwich assay for PYY using GTX60990 as the capture antibody and GTX60975 -02 as the biotinylated detection antibody.
|
REFERENCE
There are currently no references for Peptide YY antibody [04] (GTX60990). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Peptide YY antibody [04] (GTX60990). Be the first to share your experience with this product.
![Anti-Peptide YY antibody [04] used in ELISA (ELISA). GTX60990](/upload/website/prouct_img/small/GTX60990/GTX60990_20170119_ELISA_w_23061202_699.webp "Anti-Peptide YY antibody [04] used in ELISA (ELISA). GTX60990")
![Anti-Peptide YY antibody [04] used in ELISA (ELISA). GTX60990](/upload/website/prouct_img/normal/GTX60990/GTX60990_20170119_ELISA_w_23061202_699.webp "Anti-Peptide YY antibody [04] used in ELISA (ELISA). GTX60990")