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Perforin antibody [5B10]

Anti-Perforin antibody [5B10] used in IHC (Paraffin sections) (IHC-P). GTX01949

Cat. No. GTX01949

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 5B10

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($679)
See all Perforin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:20

Note :

IHC-P
The recommended fixative is 10% neutral-buffered formalin for paraffin-embedded tissue sections. Heat Induced Epitope Retreival (HIER) was performed in Epitope Retreival Solution pH6.
Not tested in other applications.

Calculated MW

61 kDa. ( Note )

Product Note

This antibofy shows cross-reactivity with smooth muscle and differentiated epithelium.

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

Recombinant prokaryotic protein corresponding to an external region of the C-terminus of the perforin molecule.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

perforin 1 , HPLH2 , P1 , PFP

Cellular Localization

Secreted , Cell membrane; Multi-pass membrane protein

Background

This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]

Database

Research Area

DATA IMAGES

Anti-Perforin antibody [5B10] used in IHC (Paraffin sections) (IHC-P). GTX01949

GTX01949 IHC-P Image

IHC-P analysis of human follicular lymphoma using GTX01949 Perforin antibody [5B10]. Note focal granular staining of occasional cytotoxic T lymphocytes.

REFERENCE

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REVIEW

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Package List Price ($)
$ 679