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Perforin antibody [ZM159]

Cat No. GTX01798

Host

Mouse

Clonality

Monoclonal

Clone Name

ZM159

Isotype

IgG2c

Application

IHC-P

Reactivity

Human
Package
500 μl ($379)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 1:100-1:200

Note :

IHC-P
Pretreatment of deparaffinized tissue with heat-induced epitope retrieval or enzymatic retrieval is recommended.

Not tested in other applications.

Calculated MW

61 kDa. ( Note )

Positive Control

Spleen

PROPERTIES

Form

Liquid

Buffer

Tris-HCl buffer, 0.2% BSA

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human Perforin protein fragment (around aa 413-552)

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

perforin 1 , HPLH2 , P1 , PFP

Cellular Localization

Secreted , Cell membrane; Multi-pass membrane protein

Background

This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]

Database

Research Area

REFERENCE

There are currently no references for Perforin antibody [ZM159] (GTX01798). Be the first to share your publications with this product.

REVIEW

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Package List Price ($)
$ 379