Form
Liquid
Buffer
PBS
Preservative
0.1% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Rat
Immunogen
Recombinant full length protein (Rat).
Purification
Protein A purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Synonyms
Perforin 1 , Cyta , Ratcyta , Prf1
Cellular Localization
Cytoplasmic granules
Background
Perforin (pore-forming protein) is originally cloned from mouse cytotoxic T-lymphocyte(CTL) (ref 1,2). It is a 555-amino acid protein with a 21-amino acid signal peptide. Perforin is a cytolytic mediator produced by killer lymphocytes, and is stored in and released by cytoplasmic granules. Perforin is involved in the killing mediated by CTL, which represents an important mechanism in the immune defense against tumors and virus infections (ref 3,4).
Research Area