GeneTex
United States (US)

Phospholamban antibody

Cat No. GTX37204

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
Not tested in other applications.

Calculated MW

6 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

0.001% Na2HPO4, 0.025% BSA, 0.0045% NaCl, 0.00025% Thimerosal, 0.00025% NaN3

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20º C or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human PLN(2-16aa EKVQYLTRSAIRRAS), identical to the related rat and mouse sequences.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

CMD1P,CMH18,PLB

Cellular Localization

Endoplasmic reticulum membrane,Membrane,Mitochondrion membrane,Sarcoplasmic reticulum membrane

Background

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
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Database

Research Area