APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| Assay dependent |
Not tested in other applications.
Calculated MW
Predict Reactivity
Human, Rat, Rabbit, Bovine, Dog, Pig, Rhesus Monkey(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
No preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Carrier-protein conjugated synthetic peptide surrounding phospho Ser16 of human phospholamban . The exact sequence is proprietary
Purification
Affinity purified by Protein A.
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
phospholamban , CMD1P , CMH18 , PLB
Cellular Localization
Endoplasmic reticulum membrane,Membrane
Background
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
Database
Research Area
DATA IMAGES
![Anti-Phospholamban (phospho Ser16) antibody [HL1710] used in Western Blot (WB). GTX637309](/templates/default/js/lightbox/images/loading.gif "Anti-Phospholamban (phospho Ser16) antibody [HL1710] used in Western Blot (WB). GTX637309")
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GTX637309 WB Image
Untreated (–) and treated (+) Mouse tissue extract (50 μg) were separated by 15% SDS-PAGE, and the membrane was blotted with Phospholamban (phospho Ser16) antibody [HL1710] (GTX637309) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
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REFERENCE
There are currently no references for Phospholamban (phospho Ser16) antibody [HL1710] (GTX637309). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Phospholamban (phospho Ser16) antibody [HL1710] (GTX637309). Be the first to share your experience with this product.
![Anti-Phospholamban (phospho Ser16) antibody [HL1710] used in Western Blot (WB). GTX637309](/upload/website/prouct_img/small/GTX637309/GTX637309_T-44774_20221021_WB_M_treatment_peptideblocking_22102723_675.webp "Anti-Phospholamban (phospho Ser16) antibody [HL1710] used in Western Blot (WB). GTX637309")
![Anti-Phospholamban (phospho Ser16) antibody [HL1710] used in Western Blot (WB). GTX637309](/upload/website/prouct_img/normal/GTX637309/GTX637309_T-44774_20221021_WB_M_treatment_peptideblocking_22102723_675.webp "Anti-Phospholamban (phospho Ser16) antibody [HL1710] used in Western Blot (WB). GTX637309")