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Precerebellin antibody

Anti-Precerebellin antibody used in Western Blot (WB). GTX85500
Anti-Precerebellin antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX85500

Cat. No. GTX85500

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all Precerebellin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 2 - 4 μg/mL.
ICC/IF 10 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

21 kDa. ( Note )

Positive Control

HEK293 Cell Lysate(GTX27902) , 3T3 Cell Lysate , 3T3/BALB Cell Slide

Product Note

This antibody is specific for Precerebellin C-Terminus

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Precerebellin antibody was raised against a 16 amino acid synthetic peptide from near the carboxy- terminus human precerebellin.The immunogen is located within the last 50 amino acids of Precerebellin.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

cerebellin 1 precursor

Cellular Localization

Secreted

Background

Precerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q (1). Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/pka- dependent signaling pathway (2); and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (3). The active form of precerebellin is highly enriched in postsynaptic structures of cerebellar Purkinje cells in cartwheel neurons of the dorsal cochlear nucleus (4). Because precerebellin belongs to the C1q/tumor necrosis factor superfamily of secreted proteins and has similarity to adiponectin and CTRP3, it has been suggested that precerebellin posseses functions other than those already stated (5).

Database

Research Area

DATA IMAGES

Anti-Precerebellin antibody used in Western Blot (WB). GTX85500

GTX85500 WB Image

WB analysis of 293 cell lysate using GTX85500 Precerebellin antibody.
Working concentration : (A) 2 and (B) 4 μg/ml

Anti-Precerebellin antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX85500

GTX85500 ICC/IF Image

ICC/IF analysis of 3T3 cells using GTX85500 Precerebellin antibody.
Working concentration : 10 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399