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Presenilin 1 antibody [C1C3]

Anti-Presenilin 1 antibody [C1C3] used in IHC (Paraffin sections) (IHC-P). GTX101028
Anti-Presenilin 1 antibody [C1C3] used in IHC (Paraffin sections) (IHC-P). GTX101028
Anti-Presenilin 1 antibody [C1C3] used in IHC (Paraffin sections) (IHC-P). GTX101028
Anti-Presenilin 1 antibody [C1C3] used in Western Blot (WB). GTX101028
Anti-Presenilin 1 antibody [C1C3] used in Western Blot (WB). GTX101028
Anti-Presenilin 1 antibody [C1C3] used in IHC (Paraffin sections) (IHC-P). GTX101028
Anti-Presenilin 1 antibody [C1C3] used in IHC (Paraffin sections) (IHC-P). GTX101028

Cat No. GTX101028

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human, Mouse, Rat
Package
100 μl ($329),
25 μl ($169)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:3000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

53 kDa. ( Note )

Positive Control

293T , A431 , Jurkat , Raji , NIH-3T3

Predict Reactivity

Dog, Pig, Rhesus Monkey(>80% identity)

PROPERTIES

Form

Liquid

Buffer

0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.29 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human Presenilin 1. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

presenilin 1 , ACNINV3 , AD3 , FAD , PS-1 , PS1 , S182

Background

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-Presenilin 1 antibody [C1C3] used in IHC (Paraffin sections) (IHC-P). GTX101028

GTX101028 IHC-P Image

Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using Presenilin 1(GTX101028) antibody at 1:100 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-Presenilin 1 antibody [C1C3] used in IHC (Paraffin sections) (IHC-P). GTX101028

GTX101028 IHC-P Image

Presenilin 1 antibody [C1C3] detects PSEN1 protein at cytosol on U373 xenograft by immunohistochemical analysis.
Sample: Paraffin-embedded U373 xenograft.
Presenilin 1 antibody [C1C3] (GTX101028) dilution: 1:200.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-Presenilin 1 antibody [C1C3] used in IHC (Paraffin sections) (IHC-P). GTX101028

GTX101028 IHC-P Image

Presenilin 1 antibody [C1C3] detects Presenilin 1 protein at cell membrane and cytoplasm in rat adrenal gland by immunohistochemical analysis.
Sample: Paraffin-embedded rat adrenal gland.
Presenilin 1 antibody [C1C3] (GTX101028) diluted at 1:500.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Presenilin 1 antibody [C1C3] used in Western Blot (WB). GTX101028

GTX101028 WB Image

Sample (30 ug of whole cell lysate)

A:NIH-3T3
10% SDS PAGE

GTX101028 diluted at 1:1000

Anti-Presenilin 1 antibody [C1C3] used in Western Blot (WB). GTX101028

GTX101028 WB Image

Sample (30 ug of whole cell lysate)
A: Raji
10% SDS PAGE
GTX101028 diluted at 1:1000

Anti-Presenilin 1 antibody [C1C3] used in IHC (Paraffin sections) (IHC-P). GTX101028

GTX101028 IHC-P Image

Presenilin 1 antibody [C1C3] detects Presenilin 1 protein at cell membrane and cytoplasm in rat lung by immunohistochemical analysis.
Sample: Paraffin-embedded rat lung.
Presenilin 1 antibody [C1C3] (GTX101028) diluted at 1:500.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Presenilin 1 antibody [C1C3] used in IHC (Paraffin sections) (IHC-P). GTX101028

GTX101028 IHC-P Image

Presenilin 1 antibody [C1C3] detects PSEN1 protein at cytosol on mouse brain by immunohistochemical analysis.
Sample: Paraffin-embedded mouse brain.
Presenilin 1 antibody [C1C3] (GTX101028) dilution: 1:200.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

REFERENCE

There are currently no references for Presenilin 1 antibody [C1C3] (GTX101028). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for Presenilin 1 antibody [C1C3] (GTX101028). Be the first to share your experience with this product.
SDS
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 329
$ 169