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United States (US)

Presenilin 1 antibody

Anti-Presenilin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31313
Anti-Presenilin 1 antibody used in Western Blot (WB). GTX31313
Anti-Presenilin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31313

Cat No. GTX31313

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P, ELISA
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5 - 2 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

53 kDa. ( Note )

Positive Control

Human Brain Tissue Slide(GTX22203) , Human Brain Tissue Lysate(GTX27918)
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Presenilin1 antibody was raised against a 23 amino acid synthetic peptide from near the carboxy terminus of human presenilin1.The immunogen is located within amino acids 330 - 380 of Presenilin1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Presenilin 1,Acninv3,Ad3,Fad,Ps-1,Ps1,S182,Psen1

Background

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]

Database

Research Area

DATA IMAGES
Anti-Presenilin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31313

GTX31313 IHC-P Image

IHC-P analysis of human brain tissue using GTX31313 Presenilin 1 antibody.
Working concentration : 2.5 μg/ml

Anti-Presenilin 1 antibody used in Western Blot (WB). GTX31313

GTX31313 WB Image

WB analysis of human brain tissue lysate using GTX31313 Presenilin 1 antibody.
Working concentration : (A) 0.5, (B) 1, and (C) 2 μg/ml

Anti-Presenilin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31313

GTX31313 IHC-P Image

IHC-P analysis of human brain tissue using GTX31313 Presenilin 1 antibody.
Working concentration : 20 μg/ml

Package List Price ($)
$ 329