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Presenilin 1 antibody

Anti-Presenilin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31313
Anti-Presenilin 1 antibody used in Western Blot (WB). GTX31313
Anti-Presenilin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31313

Cat No. GTX31313

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P, ELISA

Reactivity

Human, Mouse, Rat
Package
100 μg ($339)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5 - 2 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

53 kDa. ( Note )

Positive Control

Human Brain Tissue Slide(GTX22203) , Human Brain Tissue Lysate(GTX27918)

PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Presenilin1 antibody was raised against a 23 amino acid synthetic peptide from near the carboxy terminus of human presenilin1.The immunogen is located within amino acids 330 - 380 of Presenilin1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

presenilin 1 , ACNINV3 , AD3 , FAD , PS-1 , PS1 , S182

Cellular Localization

Endoplasmic reticulum,Endoplasmic reticulum membrane,Golgi apparatus membrane,Cell membrane

Background

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]

Database

Research Area

DATA IMAGES

Anti-Presenilin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31313

GTX31313 IHC-P Image

IHC-P analysis of human brain tissue using GTX31313 Presenilin 1 antibody.
Working concentration : 2.5 μg/ml

Anti-Presenilin 1 antibody used in Western Blot (WB). GTX31313

GTX31313 WB Image

WB analysis of human brain tissue lysate using GTX31313 Presenilin 1 antibody.
Working concentration : (A) 0.5, (B) 1, and (C) 2 μg/ml

Anti-Presenilin 1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31313

GTX31313 IHC-P Image

IHC-P analysis of human brain tissue using GTX31313 Presenilin 1 antibody.
Working concentration : 20 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf