APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500 - 1:2000 |
| 1:50 - 1:200 |
| 1:50 - 1:200 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS, 50% Glycerol
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human PSEN1 (NP_015557.2).
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
presenilin 1 , ACNINV3 , AD3 , FAD , PS-1 , PS1 , S182
Cellular Localization
Endoplasmic reticulum,Endoplasmic reticulum membrane,Golgi apparatus membrane,Cell membrane
Background
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
Database
Research Area
DATA IMAGES
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GTX55757 ICC/IF Image
ICC/IF analysis of L929 cells using GTX55757 Presenilin 1 antibody.
Blue : DAPI
Dilution : 1:100
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GTX55757 ICC/IF Image
ICC/IF analysis of C6 cells using GTX55757 Presenilin 1 antibody.
Blue : DAPI
Dilution : 1:100
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GTX55757 ICC/IF Image
ICC/IF analysis of HeLa cells using GTX55757 Presenilin 1 antibody.
Blue : DAPI
Dilution : 1:100
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GTX55757 WB Image
WB analysis of U-87MG cell lysate using GTX55757 Presenilin 1 antibody. The signal was developed with ECL plus-Enhanced.
Dilution : 1:1000
Loading : 25μg per lane
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GTX55757 IHC-P Image
IHC-P analysis of human liver tissue using GTX55757 Presenilin 1 antibody.
Dilution : 1:100
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REFERENCE
There are currently no references for Presenilin 1 antibody (GTX55757). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Presenilin 1 antibody (GTX55757). Be the first to share your experience with this product.
