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Presenilin 2 antibody [7F8]

Cat No. GTX52969

Host Mouse
Clonality Monoclonal
Clone Name 7F8
Isotype IgG1
Application WB
Reactivity Human
Package
100 μg ($329)
APPLICATION

Application Note

WB(1:500-1000)

Calculated MW

50 kDa. ( Note )

Specificity/Sensitivity

This antibody was selected for its ability to specifically detect human Presenilin-2.
PROPERTIES

Form

Liquid

Buffer

PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Human recombinant Presenilin-2

Purification

The IgG fraction of culture supernatant was purified by Protein G affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Presenilin 2,Ad3L,Ad4,Cmd1V,Ps2,Stm2,Psen2

Background

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE
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REVIEW
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SDS
PBS.pdf
Package List Price ($)
$ 329