GeneTex
  • Country / Location Selection

United States (US)

Presenilin 2 antibody [7F8]

Anti-Presenilin 2 antibody [7F8] used in Western Blot (WB). GTX52969

Cat No. GTX52969

Host

Mouse

Clonality

Monoclonal

Clone Name

7F8

Isotype

IgG1

Application

WB

Reactivity

Human
Package
100 μg ($329)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:1000
Not tested in other applications.

Calculated MW

50 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

500 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human recombinant Presenilin-2

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

AD3L , AD4 , CMD1V , PS2 , PSEN2 , STM2 , presenilin 2 , Presenilin 2

Cellular Localization

Endoplasmic reticulum membrane,Golgi apparatus membrane

Background

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Presenilin 2 antibody [7F8] used in Western Blot (WB). GTX52969

GTX52969 WB Image

WB analysis of HEK293 expressing human Presenilin-2 using GTX52969 Presenilin 2 antibody [7F8].

REFERENCE

There are currently no references for Presenilin 2 antibody [7F8] (GTX52969). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for Presenilin 2 antibody [7F8] (GTX52969). Be the first to share your experience with this product.
SDS
PBS.pdf