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Presenilin 2 antibody

Anti-Presenilin 2 antibody used in Western Blot (WB). GTX11661
Anti-Presenilin 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX11661
Anti-Presenilin 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX11661
Anti-Presenilin 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX11661

Cat. No. GTX11661

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μg ($449)
See all Presenilin 2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.1-0.5μg/ml
IHC-P 0.5-1μg/ml
Not tested in other applications.

Calculated MW

50.14 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.1% Na₂HPO₄, 0.45% NaCl, 2.5% BSA

Preservative

0.025% Thimerosal, 0.025% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

500 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Presenilin 2(39-51aa EDGENTAQWRSQE), different from the related mouse and rat sequences by two amino acids.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Cellular Localization

Endoplasmic reticulum membrane,Golgi apparatus membrane

Background

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Presenilin 2 antibody used in Western Blot (WB). GTX11661

GTX11661 WB Image

WB analysis of various samples using GTX11661 Presenilin 2 antibody.
Lane 1 : rat brain tissue lysate
Lane 2 : rat brain tissue lysate
Lane 3 : MCF-7 cell lysate
Lane 4 : HeLa cell lysate
Lane 5 : SMMC cell lysate
Lane 6 : CEM cell lysate

Anti-Presenilin 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX11661

GTX11661 IHC-P Image

IHC-P analysis of human mammary cancer tissue using GTX11661 Presenilin 2 antibody.

Anti-Presenilin 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX11661

GTX11661 IHC-P Image

IHC-P analysis of rat cardiac muscle tissue using GTX11661 Presenilin 2 antibody.

Anti-Presenilin 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX11661

GTX11661 IHC-P Image

IHC-P analysis of rat kidney tissue using GTX11661 Presenilin 2 antibody.

REFERENCE

Application Reference

Fu Y et al. J Immunother Cancer 2023; 11 (4) BRD4 inhibition impairs DNA mismatch repair, induces mismatch repair mutation signatures and creates therapeutic vulnerability to immune checkpoint blockade in MMR-proficient tumors.
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REVIEW

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SDS
Sodium Azide.pdf
Thimerosal.pdf
Package List Price ($)
$ 449