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Presenilin 2 antibody

Anti-Presenilin 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX55758
Anti-Presenilin 2 antibody used in Western Blot (WB). GTX55758
Anti-Presenilin 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX55758
Anti-Presenilin 2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX55758

Cat. No. GTX55758

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all Presenilin 2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
ICC/IF 1:50 - 1:200
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

50 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide of human PSEN2

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

presenilin 2 , AD3L , AD4 , CMD1V , PS2 , STM2

Cellular Localization

Endoplasmic reticulum membrane,Golgi apparatus membrane

Background

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Presenilin 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX55758

GTX55758 IHC-P Image

IHC-P analysis of human kidney tissue using GTX55758 Presenilin 2 antibody.
Dilution : 1:100

Anti-Presenilin 2 antibody used in Western Blot (WB). GTX55758

GTX55758 WB Image

WB analysis of various sample lysates using GTX55758 Presenilin 2 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-Presenilin 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX55758

GTX55758 IHC-P Image

IHC-P analysis of rat heart tissue using GTX55758 Presenilin 2 antibody.
Dilution : 1:100

Anti-Presenilin 2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX55758

GTX55758 ICC/IF Image

ICC/IF analysis of HeLa cells using GTX55758 Presenilin 2 antibody.
Blue : DAPI
Dilution : 1:100

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399