APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| ~0.5 μg /ml |
| Assay dependent |
Not tested in other applications.
Product Note
We do not recommend use of this product for Mouse samples.
PROPERTIES
Form
Liquid
Buffer
Filter-sterilized PBS, 50% Glycerol
Preservative
No preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant human PrP lacking GPI anchor expressed and purified from rabbit kidney cell line RK13
Purification
Purified IgG
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
prion protein , ASCR , AltPrP , CD230 , CJD , GSS , KURU , PRIP , PRNP , PrP , PrP2730 , PrP3335C , PrPc , p2730 , Prion protein PrP
Cellular Localization
Mitochondrion outer membrane,Cell membrane,Golgi apparatus,Cytoplasm,Nucleus
Background
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Database
Research Area
DATA IMAGES
![Anti-Prion Protein (PrP) antibody [7A1] used in Western Blot (WB). GTX00857](/templates/default/js/lightbox/images/loading.gif "Anti-Prion Protein (PrP) antibody [7A1] used in Western Blot (WB). GTX00857")
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GTX00857 WB Image
WB analysis of various samples using GTX00857 Prion Protein (PrP) antibody [7A1].
Lane 1 : Prion protein was overexpressed in RK13 cells
Lane 2 : Vector only in RK13 cells
Lane 3 : RK13 cells only
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REFERENCE
There are currently no references for Prion Protein (PrP) antibody [7A1] (GTX00857). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Prion Protein (PrP) antibody [7A1] (GTX00857). Be the first to share your experience with this product.
![Anti-Prion Protein (PrP) antibody [7A1] used in Western Blot (WB). GTX00857](/upload/website/prouct_img/small/GTX00857/GTX00857_20200406_AP_001_57_w_23053121_927.webp "Anti-Prion Protein (PrP) antibody [7A1] used in Western Blot (WB). GTX00857")
![Anti-Prion Protein (PrP) antibody [7A1] used in Western Blot (WB). GTX00857](/upload/website/prouct_img/normal/GTX00857/GTX00857_20200406_AP_001_57_w_23053121_927.webp "Anti-Prion Protein (PrP) antibody [7A1] used in Western Blot (WB). GTX00857")