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Prion Protein (PrP) antibody [7A1]

Anti-Prion Protein (PrP) antibody [7A1] used in Western Blot (WB). GTX00857

Cat No. GTX00857

Host

Mouse

Clonality

Monoclonal

Clone Name

7A1

Isotype

IgG1

Application

WB, ELISA

Reactivity

Human
Package
50 μg ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB ~0.5 μg /ml
ELISA Assay dependent
Not tested in other applications.

Specificity/Sensitivity

We do not recommend use of this product for Mouse.

PROPERTIES

Form

Liquid

Buffer

Filter-sterilized PBS, 50% glycerol

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human PrP lacking GPI anchor expressed and purified from rabbit kidney cell line RK13

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

prion protein , ASCR , AltPrP , CD230 , CJD , GSS , KURU , PRIP , PRNP , PrP , PrP2730 , PrP3335C , PrPc , p2730 , Prion protein PrP

Cellular Localization

Mitochondrion outer membrane,Cell membrane,Golgi apparatus,Cytoplasm,Nucleus

Background

The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Database

Research Area

DATA IMAGES

Anti-Prion Protein (PrP) antibody [7A1] used in Western Blot (WB). GTX00857

GTX00857 WB Image

WB analysis of various samples using GTX00857 Prion Protein (PrP) antibody [7A1].
Lane 1 : Prion protein was overexpressed in RK13 cells
Lane 2 : Vector only in RK13 cells
Lane 3 : RK13 cells only

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf