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Prion Protein (PrP) antibody [EM-20]

Orthogonal
Anti-Prion Protein (PrP) antibody [EM-20] used in Western Blot (WB). GTX80160

Cat. No. GTX80160

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 EM-20

Isotype

 IgG2a

Application

 WB

Reactivity

 Human
Package
100 μg ($399)
See all Prion Protein (PrP) products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
Not tested in other applications.

Product Note

This antibody is suitable for discrimination between normal cellular prion protein (PrPc) and its conformationally changed form (PrPSc) prion protein.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human prion protein

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ASCR , AltPrP , CD230 , CJD , GSS , KURU , PRIP , PRNP , PrP , PrP2730 , PrP3335C , PrPc , p2730 , prion protein , Prion protein PrP

Cellular Localization

Mitochondrion outer membrane,Cell membrane,Golgi apparatus,Cytoplasm,Nucleus

Background

The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Database

Research Area

DATA IMAGES

Anti-Prion Protein (PrP) antibody [EM-20] used in Western Blot (WB). GTX80160

GTX80160 WB Image

Orthogonal

WB analysis of Creutzfeld-Jakob disease (CJD) negative (lane 1, 2) and CJD positive (lane 3, 4) human brain material using GTX80160 Prion Protein (PrP) antibody [EM-20]. CJD positive patient has proteinase K resistent prion protein.
Lane 1, 4 : With proteinase K treatment
Lane 2, 3 : Without proteinase K treatment

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399