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Prion Protein (PrP) antibody

Cat. No. GTX20703

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ELISA

Reactivity

 Human, Mouse, Bovine
Package
50 μl ($399)
See all Prion Protein (PrP) products

APPLICATION

Application Note

The antibody is used for Western blot and ELISA (dilution 1:2000).Recognises recombinant protein ,GTX20753, in western blot and ELISA.

Product Note

Recognises natural PrPc and conformationally changed PrPc (PrPsc).

PROPERTIES

Form

Liquid

Buffer

Serum

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Bovine

Immunogen

Recombinant fragment (Cow).

Purification

Whole antiserum

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

prion protein , ASCR , AltPrP , CD230 , CJD , GSS , KURU , PRIP , PrP , PrP27-30 , PrP33-35C , PrPc , p27-30

Cellular Localization

Golgi apparatus , Mitochondrion outer membrane

Background

The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Database

Research Area

REFERENCE

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399