GeneTex
  • Country / Location Selection

United States (US)

Pro-MBP / htPAPP-A antibody [5H9]

Anti-Pro-MBP / htPAPP-A antibody [5H9] used in Western Blot (WB). GTX10191

Cat. No. GTX10191

Host

Mouse

Clonality

Monoclonal

Clone Name

5H9

Isotype

IgG2b

Application

WB, IP, ELISA

Reactivity

Human
Package
100 μg ($399)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IP Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

181 kDa. ( Note )

Product Note

This antibody is specific to proMBP subunit of the heterotetrameric complex of PAPP-A (htPAPP-A, consisting of PAPP-A subunits and proMBP subunits). It can be used to detect htPAPP-A when paired with another antibody which is specific for PAPP-A subunit.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified human PAPP-A/proMBP (heterotetrameric PAPP-A, htPAPP-A) complex.

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

pappalysin 1 , ASBABP2 , DIPLA1 , IGFBP-4ase , PAPA , PAPP-A , PAPPA1

Cellular Localization

Secreted

Background

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]

Database

Research Area

DATA IMAGES

Anti-Pro-MBP / htPAPP-A antibody [5H9] used in Western Blot (WB). GTX10191

GTX10191 WB Image

Detection of human PAPP-A and proMBP subunits of htPAPP-A by monoclonal antibodies in Western blot. Lane 1: PAPP A antibody [18A10] (GTX10196); Lane 2: PAPP A antibody [3C8] (GTX10194); Lane 3: PAPP A antibody [5H9] (GTX10191); Lane 4: PAPP A antibody [11E4] (GTX14597); Lane 5: PAPP A antibody [10A5] (GTX10193); Lane 6: PAPP A antibody [3C8] (GTX10194); Lanes 1-4: reducing conditions; Lanes 5-6: non-reducing conditions, heterotetrameric complex was detected by PAPP A antibody [10A5] (GTX10193) and PAPP A antibody [3C8] (GTX10194)

REFERENCE

There are currently no references for Pro-MBP / htPAPP-A antibody [5H9] (GTX10191). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for Pro-MBP / htPAPP-A antibody [5H9] (GTX10191). Be the first to share your experience with this product.
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399