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Progesterone Receptor antibody [4D8]

Anti-Progesterone Receptor antibody [4D8] used in Immunohistochemistry (IHC). GTX70227

Cat No. GTX70227

Host

Mouse

Clonality

Monoclonal

Clone Name

4D8

Isotype

IgG2a

Application

WB, IHC

Reactivity

Human
Package
200 μg ($499)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

99 kDa. ( Note )

Positive Control

MCF7

PROPERTIES

Form

Liquid

Buffer

Phosphate-buuffered saline, pH 7.4, containing no preservatives

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The region encoding amino acids 1-101 of the human progesterone receptor expressed in E. coli.

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Progesterone Receptor , Nr3C3 , Pr , Pgr

Background

The human Progesterone Receptor (PgR) is a member of the steroid family of nuclear receptors. PgR is found as a 120 kDa protein (Form B) or a 94 kDa protein (Form A) due to the use of alternative translation initiation sites. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. When bound to DNA, PgR can positively or negatively regulate gene transcription through the recruitment of coactivator (e.g. SRC-1) or corepressor (e.g. NCoR) proteins.

Database

Research Area

DATA IMAGES

Anti-Progesterone Receptor antibody [4D8] used in Immunohistochemistry (IHC). GTX70227

GTX70227 IHC Image

REFERENCE

There are currently no references for Progesterone Receptor antibody [4D8] (GTX70227). Be the first to share your publications with this product.

REVIEW

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