GeneTex
United States (US)

Progesterone Receptor antibody [C262], C-term

Cat No. GTX80350

Host Mouse
Clonality Monoclonal
Clone Name C262
Isotype IgG1
Application WB, IP
Reactivity Human, Mouse, Rat, Rabbit
APPLICATION

Application Note

Recommended Starting Dilutions:
Use at 5-10μg/ml
Optimal dilutions should be determined experimentally by the researcher.

Calculated MW

99 kDa. ( Note )

Specificity/Sensitivity

Human PR-A and PR-B isoforms. Cross reacts with mouse, rat and rabbit PR
PROPERTIES

Form

Liquid

Buffer

PBS + 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide to C-terminal tail of human progesterone receptor (PR). (aa 919-933 ILAGMVKPLLFHKK)

Purification

Protein G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

NR3C3, PR

Cellular Localization

Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases. Mainly nuclear.

Background

Progesterone plays a central role in the reproductive events associated with the establishment and maintenance of pregnancy. Progesterone receptor, a member of the steroid receptor superfamily, mediates the physiologic effects of progesterone. The PGR gene uses separate promoters and translational start sites to produce 2 isoforms, PRA and PRB, which are identical except for an additional 165 amino acids present only in the N terminus of PRB. Although PRA and PRB share several structural domains, they are distinct transcription factors that mediate their own response genes and physiologic effects with little overlap

Database

Research Area

Package List Price ($)
$ 319