*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji , U87-MG , MCF-7 , mouse brain
Zebrafish, Bovine, Chicken, Xenopus laevis, Rhesus Monkey(>80% identity)
1XPBS, 1% BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Recombinant protein encompassing a sequence within the center region of human Proteasome 20S alpha 1. The exact sequence is proprietary.
Purified by antigen-affinity chromatography.
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
HC2 antibody, MGC14542 antibody, MGC14575 antibody, MGC14751 antibody, MGC1667 antibody, MGC21459 antibody, MGC22853 antibody, MGC23915 antibody, NU antibody, PROS30 antibody, PSMA1 antibody, proteasome nu chain antibody, protein P30-33K antibody, macropain subunit nu antibody, PROS-30 antibody, macropain subunit C2 antibody, multicatalytic endopeptidase complex subunit C2 antibody, "proteasome subunit, alpha-type, 1 antibody", proteasome component C2 antibody, proteasome subunit nu antibody, proteasome subunit alpha type-1 antibody, 30 kDa prosomal protein antibody, "proteasome (prosome, macropain) subunit, alpha type, 1 antibody"
Cytoplasm , Nucleus
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.