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United States (US)

Prothrombin antibody [5013]

Cat. No. GTX79652

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 5013

Isotype

 IgG2a

Application

 WB, ELISA, Neutralizing/Inhibition

Reactivity

 Human
Package
100 μg ($399)
See all Thrombin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ELISA Assay dependent
Neutralizing/Inhibition Assay dependent
Not tested in other applications.

Calculated MW

70 kDa. ( Note )

Product Note

Recognises fragment 2 region of Prothrombin

PROPERTIES

Form

Liquid

Buffer

50% Glycerol

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Full length native protein (purified) (Human).

Purification

Purified by conventional chromatography

Conjugation

Unconjugated

RRID

AB_11175223

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

F2,PT,RPRGL2,THPH1,coagulation factor II, thrombin

Cellular Localization

Secreted,Extracellular space

Background

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Database

Research Area

REFERENCE

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REVIEW

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SDS
Glycerol.pdf
Package List Price ($)
$ 399