PBS with 0.02% sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
0.5mg/ml(Please refer to the vial label for the specific concentration.)
Peptide corresponding to amino acids 181 to199 of human RAIDD (1).
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain (DD)-containing receptors, TNFR1 and Fas. The death signals are transduced by a group of DD-containing adapter molecules. A novel cell death adapter was recently identified by two independent groups and designated RAIDD (RIP-associated ICH-1/CED-3-homologousprotein with DD) and CRADD (caspase and RIP adapter with DD)(1,2). RAIDD contains a DD and a CARD (for caspase recruitment domain), which interact with RIP and caspase, respectively, to transduce death signals (1,3). RAIDD is constitutively expressed in many tissues and mediates apoptosis caused by Fas and TNFR-1.