GeneTex
United States (US)

RAIDD antibody

RAIDD-antibody_WB_GTX28426-1_18121411_567.jpg
RAIDD-antibody_ICCIF_GTX28426-1_18121411_545.jpg

Cat No. GTX28426

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF
Reactivity Human
APPLICATION

Application Note

WB: Use at an assay dependent dilution. Detects a band of approximately 22 kDa. Can be blocked with GTX28460 RAIDD (internal) peptide (human) Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

23 kDa. ( Note )

Positive Control

Whole cell lysate from HeLa or K562 cells
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

0.5mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide, corresponding to amino acids 99-117 of Human RAIDD.

Purification

IgG fraction

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Background

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain (DD)-containing receptors, TNFR1 and Fas. The death signals are transduced by a group of DD-containing adapter molecules. A novel cell death adapter was recently identified by two independent groups and designated RAIDD (RIP-associated ICH-1/CED-3-homologousprotein with DD) and CRADD (caspase and RIP adapter with DD)(1,2). RAIDD contains a DD and a CARD (for caspase recruitment domain), which interact with RIP and caspase, respectively, to transduce death signals (1,3). RAIDD is constitutively expressed in many tissues and mediates apoptosis caused by Fas and TNFR-1.

Database

Research Area

DATA IMAGES
RAIDD-antibody_WB_GTX28426-1_18121411_567.jpg

GTX28426 WB Image

Western blot analysis of RAIDD in whole cell lysates from HeLa (H) or K562 (K) cells with Anti-RAIDD (IN) (Cat. No. GTX28426) at 1:500 dilution.

RAIDD-antibody_ICCIF_GTX28426-1_18121411_545.jpg

GTX28426 ICC/IF Image

Immunocytochemical staining of RAIDD in HeLa cells with RAIDD antibody (GTX28426) at 5μg/ml.

Package List Price ($)
$ 329