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RANBP2 antibody

Anti-RANBP2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX00729
Anti-RANBP2 antibody used in Western Blot (WB). GTX00729

Cat No. GTX00729

Host

Rabbit

Clonality

Polyclonal

Application

WB, ICC/IF, IP

Reactivity

Human, Mouse, Rat
Package
100 μl ($349)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB ~1:1000
ICC/IF Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

358 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Undiluted Serum, 0.09% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

synthetic peptide corresponding to 3 times-repeated sequences in RanBP2; SKAPKSGFEGMFTKKE

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

RAN binding protein 2 , ADANE , ANE1 , IIAE3 , NUP358 , TRP1 , TRP2

Cellular Localization

Nucleus

Background

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-RANBP2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX00729

GTX00729 ICC/IF Image

ICC/IF analysis of HeLa cells using GTX00729 RANBP2 antibody.
Dilution : 1:2000
Fixation : 4% PFA

Anti-RANBP2 antibody used in Western Blot (WB). GTX00729

GTX00729 WB Image

WB analysis of HeLa whole cell lysate using GTX00729 RANBP2 antibody.
Dilution : 1:1000

REFERENCE

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REVIEW

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Package List Price ($)
$ 349