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RANK antibody

Anti-RANK antibody used in Western Blot (WB). GTX11697
Anti-RANK antibody used in IHC (Paraffin sections) (IHC-P). GTX11697

Cat. No. GTX11697

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μg ($449)
See all RANK products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.1-0.5μg/ml
IHC-P 0.5-1μg/ml
Not tested in other applications.

Calculated MW

66.03 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.1% Na₂HPO₄, 0.45% NaCl, 2.5% BSA

Preservative

0.025% Thimerosal, 0.025% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

500 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human RANK(29-44aa QIAPPCTSEKHYEHLG).

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Cellular Localization

Cell membrane,Cell membrane

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]

Database

  • Gene ID: 8792 TNFRSF11A
  • UniProt: Q9Y6Q6 TNFRSF11A

Research Area

DATA IMAGES

Anti-RANK antibody used in Western Blot (WB). GTX11697

GTX11697 WB Image

WB analysis of various samples using GTX11697 RANK antibody.
Lane 1 : Recombinant human RANK protein 10ng
Lane 2 : Recombinant human RANK protein 5ng
Lane 3 : Recombinant human RANK protein 2.5ng

Anti-RANK antibody used in IHC (Paraffin sections) (IHC-P). GTX11697

GTX11697 IHC-P Image

IHC-P analysis of human mammary cancer tissue using GTX11697 RANK antibody.

REFERENCE

Application Reference

X Zeng et al. Pharmacognosy Magazine 2023; Bee Pollen Stimulated BMP2 and RANK Signaling Pathway in Osteoprogenitors and Improved Bone Mineralization in Rat Model of Femur Fracture
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REVIEW

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SDS
Sodium Azide.pdf
Thimerosal.pdf
Package List Price ($)
$ 449