APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500 - 1:2000 |
| 1:50 - 1:100 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS, 50% Glycerol
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human RAP1A (NP_002875.1).
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
RAP1A, member of RAS oncogene family , C21KG , G-22K , KREV-1 , KREV1 , RAP1 , SMGP21
Cellular Localization
Cell membrane,Cytoplasm,Cell junction
Background
This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Database
Research Area
DATA IMAGES
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GTX64554 IHC-P Image
IHC-P analysis of mouse spleen tissue using GTX64554 RAP1A antibody.
Dilution : 1:100
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GTX64554 IHC-P Image
IHC-P analysis of human liver cancer tissue using GTX64554 RAP1A antibody.
Dilution : 1:100
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GTX64554 WB Image
WB analysis of various sample lysates using GTX64554 RAP1A antibody.
Dilution : 1:1000
Loading : 25μg per lane
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GTX64554 IHC-P Image
IHC-P analysis of human colon carcinoma tissue using GTX64554 RAP1A antibody.
Dilution : 1:100
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REFERENCE
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REVIEW
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