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RHBDD3 antibody

Anti-RHBDD3 antibody used in IHC (Paraffin sections) (IHC-P). GTX85218
Anti-RHBDD3 antibody used in Western Blot (WB). GTX85218

Cat. No. GTX85218

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all RHBDD3 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 μg/mL
IHC-P 20 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

40 kDa. ( Note )

Positive Control

Rat Lung Tissue Lysate(GTX27941)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

RHBDD3 antibody was raised against a 13 amino acid synthetic peptide from near the center of human RHBDD3.The immunogen is located within amino acids 170 - 220 of RHBDD3.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

rhomboid domain containing 3 , C22orf3 , HS984G1A , PTAG

Cellular Localization

Membrane

Background

The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD3 was initially identified as a novel pituitary tumor apoptosis gene (PTAG) whose expression was reduced in certain pituitary adenomas. Overexpression of RHBDD3 in AtT20 cells showed an increase in apoptotic activity and caspase activation in response to bromocriptine, and apoptosis-inducing dopamine D2 analog, suggesting that reactivation of RHBDD3 in tumors may be a therapeutically useful tool. Later experiments also showed that RHBDD3 expression is also reduced in several primary colorectal tumors, indicating that loss of RHBDD3 contributes to a blunted apoptotic response and probably predisposes cells towards malignant transformation.

Database

Research Area

DATA IMAGES

Anti-RHBDD3 antibody used in IHC (Paraffin sections) (IHC-P). GTX85218

GTX85218 IHC-P Image

IHC-P analysis of rat lung tissue using GTX85218 RHBDD3 antibody.
Working concentration : 20 μg/ml

Anti-RHBDD3 antibody used in Western Blot (WB). GTX85218

GTX85218 WB Image

WB analysis of rat lung tissue lysate using GTX85218 RHBDD3 antibody.
Working concentration : 1 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399