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RIP2 antibody [Nick-1]

Cat. No. GTX17328

Host

 Rat

Clonality

 Monoclonal

Clone Name

 Nick-1

Isotype

 IgG2a

Application

 WB

Reactivity

 Human
Package
50 μg ($399)
See all RIP2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1,000
Not tested in other applications.

Calculated MW

61 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment, corresponding to N terminal amino acids 1-322 of Human RIP2.

Purification

Purified IgG2a

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

receptor interacting serine/threonine kinase 2 , CARD3 , CARDIAK , CCK , GIG30 , RICK , RIP2

Cellular Localization

Cytoplasm

Background

Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD containing serine/threonine kinase RIP regulates Fas induced apoptosis. A novel CARD containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP like interacting CLARP kinase, receptor interacting protein 2, and CARD containing ICE associated kinase, respectively. RICK contains an N terminal kinase catalytic domain and a C terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF kB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase 1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced apoptosis and that is involved in the generation of proinflammatory cytokine IL1b. The messenger RNA of RICK is expressed in multiple human tissues.

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399