GeneTex

  • Country / Location Selection

United States (US)

RPE65 blocking peptide

Cat. No. GTX88833-PEP

Species

 Human
Package
100 μg ($239)

APPLICATION

Product Note

The peptide was used in the production of GTX88833.

PROPERTIES

Form

Lyophilized powder

Buffer

Reconstitute with 200μl distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O.

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Region/Sequence

C-EVKKNARKAPQPE

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Rpe65, Retinoid Isomerohydrolase , Bco3 , Lca2 , Rp20 , Mrpe65 , P63 , Rd12 , Srpe65 , Rpe65

Background

This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq, Jul 2008]

Research Area

REFERENCE

There are currently no references for RPE65 blocking peptide (GTX88833-PEP). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for RPE65 blocking peptide (GTX88833-PEP). Be the first to share your experience with this product.
Submit a Review
Package List Price ($)
$ 239