*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
HepG2 , Jurkat , Mouse brain
Rat, Zebrafish, Sheep, Bovine, Dog, Chicken, Pig, Xenopus laevis, Rhesus Monkey(>80% identity)
1XPBS, 1% BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
1mg/ml(Please refer to the vial label for the specific concentration.)
Recombinant protein encompassing a sequence within the center region of human RPSA. The exact sequence is proprietary.
Purified by antigen-affinity chromatography.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
37LRP antibody, 67LR antibody, LAMBR antibody, LAMR1 antibody, LBP antibody, LRP antibody, p40 antibody, RPSA antibody, multidrug resistance-associated protein MGr1-Ag antibody, laminin binding protein antibody, 40S ribosomal protein SA antibody, 37 kDa laminin receptor antibody, 37/67 kDa laminin receptor antibody, 67 kDa laminin receptor antibody, "67kD, ribosomal protein SA antibody", laminin-binding protein precursor p40 antibody, "laminin receptor 1 (67kD, ribosomal protein SA) antibody", colon carcinoma laminin-binding protein antibody, ribosomal protein SA antibody
Cell membrane , Cytoplasm (By similarity) , Nucleus (By similarity)
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]