GeneTex
United States (US)

RUNX2 antibody

GTX38531_20190129_IHC-P_19012901_416.jpg
GTX38531_20190129_WB_19012901_154.jpg

Cat No. GTX38531

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human, Rat
APPLICATION

Calculated MW

57 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

0.001% Na2HPO4, 0.025% BSA, 0.0045% NaCl, 0.00025% Thimerosal, 0.00025% NaN3

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20º C or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human RUNX2 (244-258aa DRLSDLGRIPHPSMR), identical to the related rat and mouse sequences.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Runt Related Transcription Factor 2,Aml3,Cbf-Alpha-1,Cbfa1,Ccd,Ccd1,Clcd,Osf-2,Osf2,Pea2Aa,Pebp2Aa,Runx2

Cellular Localization

Nucleus

Background

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016]

Database

Research Area

DATA IMAGES
GTX38531_20190129_IHC-P_19012901_416.jpg

GTX38531 IHC-P Image

IHC-P analysis of human bone sarcoma tissue using GTX38531 RUNX2 antibody.

GTX38531_20190129_WB_19012901_154.jpg

GTX38531 WB Image

WB analysis of rat tissue lysate using GTX38531 RUNX2 antibody.

Package List Price ($)
$ 249