0.001% Na2HPO4, 0.025% BSA, 0.0045% NaCl, 0.00025% Thimerosal, 0.00025% NaN3
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20º C or below. Avoid multiple freeze-thaw cycles.
A synthetic peptide corresponding to a sequence in the middle region of human RUNX2 (244-258aa DRLSDLGRIPHPSMR), identical to the related rat and mouse sequences.
Purified by antigen-affinity chromatography
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Runt Related Transcription Factor 2,Aml3,Cbf-Alpha-1,Cbfa1,Ccd,Ccd1,Clcd,Osf-2,Osf2,Pea2Aa,Pebp2Aa,Runx2
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016]