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RUNX2 antibody

Anti-RUNX2 antibody used in Western Blot (WB). GTX38531
Anti-RUNX2 antibody used in IHC (Paraffin sections) (IHC-P). GTX38531

Cat. No. GTX38531

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Rat
Package
50 μg ($399)
See all RUNX2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

57 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.001% Na₂HPO₄, 0.025% BSA, 0.0045% NaCl

Preservative

0.00025% Thimerosal, 0.00025% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human RUNX2 (244-258aa DRLSDLGRIPHPSMR), identical to the related rat and mouse sequences.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

runt related transcription factor 2 , AML3 , CBF-alpha-1 , CBFA1 , CCD , CCD1 , CLCD , OSF-2 , OSF2 , PEA2aA , PEBP2aA

Cellular Localization

Nucleus

Background

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016]

Database

Research Area

DATA IMAGES

Anti-RUNX2 antibody used in Western Blot (WB). GTX38531

GTX38531 WB Image

WB analysis of rat tissue lysate using GTX38531 RUNX2 antibody.

Anti-RUNX2 antibody used in IHC (Paraffin sections) (IHC-P). GTX38531

GTX38531 IHC-P Image

IHC-P analysis of human bone sarcoma tissue using GTX38531 RUNX2 antibody.

REFERENCE

Application Reference

Xuan Y et al. Int J Nanomedicine 2023; 18 : 917-932 The 3D-Printed Ordered Bredigite Scaffold Promotes Pro-Healing of Critical-Sized Bone Defects by Regulating Macrophage Polarization.
Application : IHC-P
Reactivity : Rat
Submit a Reference

REVIEW

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SDS
Thimerosal.pdf
Package List Price ($)
$ 399