Rad50 antibody [13B3]
Cat. No. GTX70228
Cat. No. GTX70228
This Rad50 antibody [13B3] (GTX70228) is a mouse monoclonal antibody validated for detection of Rad50 by WB, ICC/IF, IHC-P, IP, ChIP assay, IHC, in vitro, and PLA. Reactivity has been shown in Human, Mouse, Rat, and other species. This product is cited in 129 published studies. Knockout/knockdown validation supports antibody specificity.
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HostMouse
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ClonalityMonoclonal
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Clone Name13B3
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IsotypeIgG1
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ApplicationsWB ICC/IF IHC-P IP ChIP assay IHC in vitro PLA
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ReactivityHuman, Mouse, Rat, Monkey
Summary
Rad50 antibody detects RAD50, a ~154 kDa protein that, together with MRE11 and NBS1, forms the MRN complex that is intimately involved in DNA damage signaling, DNA double-strand break (DSB) repair, recombination, and replication. The complex is also involved other facets of genomic homeostasis including telomere maintenance. MRN plays a pivotal role in the DNA damage response (DDR) through interactions with ATM and ATR.