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Rad51 antibody (Agarose)

Cat No. GTX00878

Host

Chicken

Clonality

Polyclonal

Isotype

IgY

Application

IP

Reactivity

Human, Mouse, Rat, Chicken
Package
100 μl ($349)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IP Assay dependent

Note :

IP
Identification of proteins physically interacting with Rad51 protein by immuno-coprecipaitation.

Not tested in other applications.

Calculated MW

37 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Filter-sterilized PBS, 0.09% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antibody was raised by immunizing chicken with full-size recombinant human Rap51 protein.

Purification

Purified IgY
From the egg yolk

Conjugation

Agarose
This antibody was conjugated with Chicken IgY, and the IgY was conjugated with cyanogen bromide-activated Agarose (Sepharose). Chicken IgY antibodies have less backgrounds than mammalian IgG antibodies in immuno-reactions. And 100 μl suspension contains 280 μg of IgY.

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

RAD51 recombinase , BRCC5 , FANCR , HRAD51 , HsRad51 , HsT16930 , MRMV2 , RAD51 , RAD51A , RECA , Rad51

Cellular Localization

Nucleus,Cytoplasm,Perinuclear region,Mitochondrion matrix,Cytoskeleton,Microtubule organizing center,Centrosome

Background

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 349